Treatment of childhood depression with antidepressant drugs.

Treatment of childhood depression with antidepressant drugs.

Wishful thinking: antidepressant drugs in childhood depression.

The use of selective serotonin reuptake inhibitors (SSRIs) in children under 18 inhibitors (SSRIs) in children under 18 years old increased tenfold (from 0.5 to years old increased tenfold (from 0., despite the existence of training and theoretical models existence of training and theoretical models for the treatment of mental disorders that for the treatment of mental disorders that are simila...

Can long-term treatment with antidepressant drugs worsen the course of depression?

BACKGROUND The possibility that antidepressant drugs, while effectively treating depression, may worsen its course has received inadequate attention. METHOD A review of the literature suggesting potential depressogenic effects of long-term treatment with antidepressant drugs was performed. A MEDLINE search was conducted using the keywords tolerance, sensitization, antidepressive agents, and s...

Antidepressant treatment of depression: a metaanalysis.

OBJECTIVE To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. METHOD A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine stu...

Caffeine metabolism during prolonged treatment of rats with antidepressant drugs.

Our previous studies showed that some of the tested antidepressants (tricyclics, SSRIs, mirtazapine, nefazodone) directly inhibited the metabolism of caffeine when added in vitro to liver microsomes. The aim of the present study was to investigate a possible indirect effect of prolonged in vivo administration of these antidepressants on the rate of caffeine oxidative metabolism: 1-N-, 3-N- and ...